Rotarod analysis of untreated and PPS-treated MPS VI rats.

<p>Rotarod performance was assessed monthly in the untreated and PPS-treated MPS VI rats. Data is shown for all animals (n = 10/group) at 9 months of age, prior to sacrifice. White boxes, untreated MPS VI rats; light gray boxes, group 1 treated MPS VI rats; dark gray boxes, group 2 treated MPS VI rats; and black boxes, group 3 treated MPS VI rats. The vertical lines in each column indicate the ranges. The dotted horizontal line depicts the length of time that normal rats could remain on the rotarod at all speeds (120 s). In each of the treatment groups there was a significant improvement in the rotarod performance compared to untreated MPS VI rats (*P<0.05). This occurred at all speeds. Note that at or above 30 rpm the untreated MPS VI rats could not remain on the rotating bar.