Figure 5

<p>Release of ATP is normal in <i>RhoF^−/−</i> mice in response to thrombin (<b>A</b>) and CRP (<b>B</b>) showing that Rif is not required for dense granule secretion. Data are presented as mean ± SEM of at least 4 mice per group. Similarly, expression of P-selectin induced by thrombin stimulation is normal over a range of concentrations (<b>C</b>) and follows a similar time course to that in wild-type controls (<b>D</b>). Rif does not therefore appear to be required for the cytoskeletal rearrangements required for alpha granule secretion in mouse platelets. Data are presented as mean ± SEM of at least 3 mice per group.