Dynamic thrombin generation during the course of pregnancy.

<p>Thrombin generating capacity was determined empirically using a thrombin generation assay. Each point (circle) in the figure is representative of a single individual's thrombin generating capacity. A video showing changes in the dynamic thrombin generating capacity during pregnancy can be viewed from the <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0054728#pone.0054728.s005" target="_blank">Movie S5</a>. All subjects, including the 3 highlighted (P1: pregnant subject 1, P2: pregnant subject 2 and P3: pregnant subject 3), have increased thrombin generating capacity (decreased lag time, increased maximal rate, increased peak and total thrombin) in early pregnancy. The thrombin generation capacity increases further in late pregnancy and post-pregnancy returns to near baseline levels for most individuals. Note that the peak thrombin scale ranges from 0–750 nM.