Albumin overload induces proteinuria and upregulates pro-inflammatory cytokine expression in isolated mouse glomeruli.

<p><i>A</i>, Urinary protein normalized to urinary creatinine in mice injected with saline (open bar) or low endotoxin bovine serum albumin (BSA; closed bar; n = 4 animals per group). * denotes P = 0.004 compared to saline injected controls. <i>B</i>, IL-1β expression in isolated glomeruli from mice injected with saline (open bar) or BSA (closed bar; n = 4 animals per group). * denotes P = 0.02 compared to controls. <i>C</i>, TNF expression in isolated glomeruli from mice injected with saline (open bar) or BSA (closed bar; n = 4 animals per group). * denotes P = 0.02 compared to controls. <i>D</i>, IL-6 expression in isolated glomeruli from mice injected with saline (open bar) or BSA (closed bar; n = 4 animals per group).