Pathway analysis of genes regulated by 100 nM or 20 nM endoxifen treatments in the presence of estrogen and physiologically relevant levels tamoxifen and its metabolites.

<p> The sub-categories of biological pathways determined to be significantly altered and which were unique to the 100 nM endoxifen treatment (<b>A</b>) or the 20 nM endoxifen treatment (<b>B</b>), or which were commonly regulated by both endoxifen concentrations (<b>C</b>), are shown. The specific biological pathways which are comprised within these sub-categories are listed in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0054613#pone-0054613-t001" target="_blank">Table 1</a>.