<p>Panels (<b>A</b>) and (<b>C</b>) show a sketch of the two different behaviours one can obtain for the density of ribosomes and the current , respectively. The genes are divided in two categories, according to the shape of , as shown in (<b>A</b>): <i>abrupt</i> mRNAs (red, colour online) present a steep increase of the polysome size with increasing the initiation rate. On the other and, <i>smooth</i> sequences (blue, colour online) do not show this feature. The current (<b>C</b>) is also affected, with <i>abrupt</i> genes exhibiting a sudden change, or ‘kink’ in the current, while the current of <i>smooth</i> mRNAs does not suddenly saturate. Panels (<b>B</b>) and (<b>D</b>) show the outcome of numerical simulations of real sequences fr...
<p><b>Copyright information:</b></p><p>Taken from "Dissecting eukaryotic translation and its control...
A stochastic model based on tape theory of mRNA function is developed. It is assumed that (i) transc...
Proteins are polymerized by cyclic machines called ribosomes, which use their messenger RNA (mRNA) t...
Translation of mRNA into protein is a fundamental yet complex biological process with multiple facto...
<p>Panel (a) shows the distribution of the number of ribosomes on an mRNA chain of 1025 codons at tw...
The interplay between turnover or degradation and ribosome loading of messenger RNA (mRNA) is studie...
<div><p>Recent studies have demonstrated how the competition for the finite pool of available gene e...
In prokaryotes, transcription and translation are dynamically coupled, as the latter starts before t...
The process of transcription initiation and elongation are primary points of control in the regulati...
(A) The transcriptome in the model consists of two types of mRNAs: background mRNAs which are consid...
<p>Ribosomes (shaded in grey), modeled as extended particles that occupy 10 codons (black boxes), jo...
Many viruses can produce multiple proteins from a single mRNA sequence by encoding the proteins in o...
Computational modelling of in vivo protein synthesis is highly complicated, as it requires the simul...
<p>Deterministic (A, C) and the corresponding stochastic (B, D) time evolution of RNA, protein and m...
<p><b>(A)</b> In a simulation of the translation of yeast coding sequences, the average relative elo...
<p><b>Copyright information:</b></p><p>Taken from "Dissecting eukaryotic translation and its control...
A stochastic model based on tape theory of mRNA function is developed. It is assumed that (i) transc...
Proteins are polymerized by cyclic machines called ribosomes, which use their messenger RNA (mRNA) t...
Translation of mRNA into protein is a fundamental yet complex biological process with multiple facto...
<p>Panel (a) shows the distribution of the number of ribosomes on an mRNA chain of 1025 codons at tw...
The interplay between turnover or degradation and ribosome loading of messenger RNA (mRNA) is studie...
<div><p>Recent studies have demonstrated how the competition for the finite pool of available gene e...
In prokaryotes, transcription and translation are dynamically coupled, as the latter starts before t...
The process of transcription initiation and elongation are primary points of control in the regulati...
(A) The transcriptome in the model consists of two types of mRNAs: background mRNAs which are consid...
<p>Ribosomes (shaded in grey), modeled as extended particles that occupy 10 codons (black boxes), jo...
Many viruses can produce multiple proteins from a single mRNA sequence by encoding the proteins in o...
Computational modelling of in vivo protein synthesis is highly complicated, as it requires the simul...
<p>Deterministic (A, C) and the corresponding stochastic (B, D) time evolution of RNA, protein and m...
<p><b>(A)</b> In a simulation of the translation of yeast coding sequences, the average relative elo...
<p><b>Copyright information:</b></p><p>Taken from "Dissecting eukaryotic translation and its control...
A stochastic model based on tape theory of mRNA function is developed. It is assumed that (i) transc...
Proteins are polymerized by cyclic machines called ribosomes, which use their messenger RNA (mRNA) t...