Contour plots showing how generation time (<i>T</i>), basic reproductive number (<i>R</i>₀) and the proportion of transmitters in the population (<i>u</i>) co-vary.

<p>Gray bands highlight different values of <i>u</i>. The area between the white dashed lines represents <i>R</i>₀ values estimated by sensitivity analysis of mortality and recovery rate (<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1002876#pcbi.1002876.s007" target="_blank">Table S3</a>). The area between the yellow dashed lines represents the 95% confidence limits of <i>R</i>₀ values estimated assuming 40 years of infectivity and 70 years of life expectancy. The black dots show the maximum <i>T</i> value for each subtype, which is defined by empirical values for <i>u</i> and the median values of <i>R</i>₀ (see text).