Downregulation of CTGF inhibits GBM02 cell migration.

<p>Representative images of HE stained migrated cells. GBM 02 cells (A) GBM02 platted with P0 neurons (B) Graph showing the percentage of cells that migrate in each condition (C). GBM02 were transfected with control siRNA (D) or siRNA to down regulate CTGF expression (E). Statistical analysis of the effects with P0 neurons and downregulation of CTGF on the GBM02 migration (F). Downregulation of CTGF dramatically reduced GBM02 cell migration in vitro. <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0055605#s3" target="_blank">Results</a> are mean±SD from three experiments each performed in duplicate. The numbers of invasive cells were significant different from the control group (*p<0.05 and **p<0.01).