Selectivity of C646 for primary AE-positive AML blasts.

<p>The AML blasts were respectively isolated from the bone marrow samples of 2 t(8;21)(q22;q22) AML patients and a normal karyotype AML patient. The normal hematopoietic stem cells were isolated from granulocyte colony-stimulating factor-mobilized PBSCs of 2 healthy donors. The cells were cultured with given doses of C646 or 0.1% DMSO for 24 h before being subjected to the cell cycle distribution (A), apoptosis (B) or colony formation (C) assays. Histogram showed means ± SD for 2 independent experiments with triplicate cultures. * <i>P</i><0.05.