Effects of Cd on cytotoxicity and insulin secretion in RIN-m5F cells.

<p>(A) Cells were treated with or without CdCl₂ (1–10 μM) for 24 h, and cell viability was determined by MTT assay. (B) Insulin secretion from RIN-m5F cells with or without CdCl₂ (5 and 10 μM) in the absence or presence of NAC (1 mM) for 4 h was detected under 20 mM glucose-stimulated condition. Data are expressed as mean ± S.D. for six independent experiments with triplicate determination. *<i>p</i><0.05 as compared with vehicle control. <b>^#</b><i>p</i><0.05 as compared with cadmium alone.