<p>(A) Longevities of foci recorded in unstressed MRC5 cells and the unstressed D-NHEJ and B-NHEJ model simulations. (B)Longevities of foci recorded in unstressed MRC5 cells and the stressed D-NHEJ and B-NHEJ model simulations with ROS production increased 2.5 times. Simulated data shows no change other than an increase in the number of breaks produced. (C) Survival curves of short lived foci (8 hours and less) for resting and stressed MRC5 cells (dotted lines) and resting and stressed simulated data (solid lines).</p
<p>Default values of the parameters, for a normal, non-proliferating cell, and range of variations o...
<p>(A) Example time-series of cell growth rate for a cell with fast (green), slow (blue) and very sl...
<p>Graphs with different values of the pressure interval show how the predicted health of epithelial...
<p>Simulated (solid) and experimental (dotted) DNA damage foci survival curves are not statistically...
<p>Time courses for ROS, DNA damage foci, p53 and p21 for two representative simulation of the integ...
<p>a, experimental data (circled) were fitted by model Eq. 3a–d using Eq. 4 as an expression for mon...
<p>Cell populations that divide asymmetrically have a smaller average damage level and a higher fra...
<p>A) Ligand-receptor cooperativity for RTK submodel (dots-deterministic simulations; lines- hill eq...
<p>Several groups have documented persistent MT growth (low catastrophe) in the cell interior. We si...
<p>(a) Phase contrast microscopy images and flow cytometry profiles showing cell cycle phenotypes of...
(A) Analysis of RAD51 distribution by recovery time. Four substages were considered (MP: mid pachyte...
<p>Images of unstressed (A) and stressed (B) cells expressing the fusion protein AcGFP-53BP1c. Scale...
<p><b>A</b>: Results of a typical run at the exponential growth phase and at equilibrium (type A cel...
<p>The time courses for number of molecules of ROS, DNA damage foci, p53 and p21 for two representat...
<p><i>(A)</i>–<i>(C)</i> Random molecular damage triggering infectious molecular damage at a constan...
<p>Default values of the parameters, for a normal, non-proliferating cell, and range of variations o...
<p>(A) Example time-series of cell growth rate for a cell with fast (green), slow (blue) and very sl...
<p>Graphs with different values of the pressure interval show how the predicted health of epithelial...
<p>Simulated (solid) and experimental (dotted) DNA damage foci survival curves are not statistically...
<p>Time courses for ROS, DNA damage foci, p53 and p21 for two representative simulation of the integ...
<p>a, experimental data (circled) were fitted by model Eq. 3a–d using Eq. 4 as an expression for mon...
<p>Cell populations that divide asymmetrically have a smaller average damage level and a higher fra...
<p>A) Ligand-receptor cooperativity for RTK submodel (dots-deterministic simulations; lines- hill eq...
<p>Several groups have documented persistent MT growth (low catastrophe) in the cell interior. We si...
<p>(a) Phase contrast microscopy images and flow cytometry profiles showing cell cycle phenotypes of...
(A) Analysis of RAD51 distribution by recovery time. Four substages were considered (MP: mid pachyte...
<p>Images of unstressed (A) and stressed (B) cells expressing the fusion protein AcGFP-53BP1c. Scale...
<p><b>A</b>: Results of a typical run at the exponential growth phase and at equilibrium (type A cel...
<p>The time courses for number of molecules of ROS, DNA damage foci, p53 and p21 for two representat...
<p><i>(A)</i>–<i>(C)</i> Random molecular damage triggering infectious molecular damage at a constan...
<p>Default values of the parameters, for a normal, non-proliferating cell, and range of variations o...
<p>(A) Example time-series of cell growth rate for a cell with fast (green), slow (blue) and very sl...
<p>Graphs with different values of the pressure interval show how the predicted health of epithelial...