Melphalan resistance is accompanied by increased resistance to agents inducing non-bulky BER substrates.

<p>Cell were exposed to MMS (A), H₂O₂ (B), low (C) and high (D) doses of 5-FU, MMC (E) and UVB (F) assessed by the MTT assay. Viability curves showed that the Melphalan-resistant cells are cross-resistant to MMS, H₂O₂, low dose 5-FU and MMC. Conversely, high dose of 5-FU affects the proliferation of resistant cells in higher extent compared to sensitive cells. Exposure to UVB similarly affected growth of both cell lines. Increasing absorbance correlates directly with the number of living cells. Standard deviation bars are indicated.