Identification of tissue-specific genes expressed during WNV infection.

<p>(<b>A</b>) Venn diagram between spleen and liver tissues from WT infected mice. (<b>B</b>) Hierarchical clustering of 658 differentially expressed genes between liver from WT and KO infected mouse strains. Differentially expressed genes are shown as log₁₀(ratio) of WNV-infected to strain-matched mock-infected mice. Genes whose expression was significantly induced over strain-matched mock-infected mice are depicted in the heat map (1.5 fold; <i>P</i>≤0.01). Clustering was performed using hierarchical UPGMA (unweighted average) with Euclidean distance similarity measure in Spotfire DecisionSite. Functional annotation was performed using the DAVID Bioinformatics Resource version 6.7 and gene ontology accession numbers for biological processes FAT are listed. G-protein coupled receptor (GPCR).