A schematic diagram showing the contribution of MUC4 in the overall aggressiveness of TNBC cells.
- Partha Mukhopadhyay (10872)
- Imayavaramban Lakshmanan (281140)
- Moorthy P. Ponnusamy (198966)
- Subhankar Chakraborty (230378)
- Maneesh Jain (281141)
- Priya Pai (281142)
- Lynette M. Smith (230384)
- Subodh M. Lele (122057)
- Surinder K. Batra (120446)
Publication date
February 2013
DOIAbstract
<p>MUC4 maintains the sustained expression of EGFR family proteins and thereby potentiates downstream signaling events mediated through the PKC-γ and Erk1/2 signaling. MUC4 maintains sustained expression of β-catenin, which induces proliferation, tumorigenesis, migration, invasion, and metastasis.</p
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