BA treatment of TRAMP mice inhibits growth of prostate tumors.

<p>(<b>A</b>) Weights of primary prostate tumors were significantly less in BA (5, 10 mg/kg) compared to vehicle control [C] treated TRAMP mice (*, <i>P</i><0.03; **, <i>P</i><0.002). (<b>B</b>) BA10 treatment increased cleaved caspase-3 + cells and decreased CD31 and Ki67 + cells compared to control prostate tumors. (<b>C</b>) Representative immunostaining for cyclin D1 and AR (×200) showed less protein in BA10 compared to control prostate tumors (PT). AR protein levels were similar in normal prostates (Pr) from mice treated with BA or control (×200). (<b>D</b>) Significantly decreased number of AR + cells in BA10 compared to control prostate tumors (*, <i>P</i><4×10⁻⁷).