BA increases degradation of multiple cell cycle and pro-survival proteins.

<p>(<b>A</b>) Western blot analysis showed that BA treatment lowered the protein levels of cyclins, Cdks, E2F1, and Rb in LNCaP and PC3 cells. In contrast, BA treatment increased the protein levels of the Cdk inhibitor p27. (<b>B</b>) BA treatment decreased pro-survival proteins AR, AKT, survivin, and Mcl-1, which correlated with increased cl-PARP in LNCaP and PC3. AR in PC3 was from transient transfection.