Binding of antibodies to immobilized Z domain variants.
- Feifan Yu (281451)
- Peter Järver (281452)
- Per-Åke Nygren (73380)
Publication date
February 2013
DOIAbstract
<p>(<b>A-D</b>): Overlay of sensorgram traces obtained after injection of four different mouse IgG<sub>1</sub> monoclonal antibodies (one per panel) over separate sensor chip surfaces containing similar amounts of the variants Z<sub>F5I</sub>, Z<sub>F5R</sub> or the wild type Z domain (Z<sub>WT</sub>), respectively. (E): Overlay of sensorgram traces obtained after injection of a TNF-alpha receptor:human IgG1 Fc fusion protein (etanercept, Enbrel®) over separate sensor chip surfaces containing similar amounts of the variants Z<sub>F5I</sub>, Z<sub>F5R</sub> or the wild type Z domain (Z<sub>WT</sub>), respectively.</p
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