Expression of cholesterol metabolizing genes shows a strong time dependence.

<p>(A) The cholesterol biosynthesis pathway from squalene-PP (top left) to cholesterol (top right) showing all enzymes and some intermediates. Enzymes whose gene expression patterns fall into the largest cluster seen in the heatmap of the expression levels for these enzymes (B) are colored purple, other enzymes are light blue. LIPA and SOAT1/2 interconvert cholesterol and cholesterol ester. The cholesterol sensitive miRNA-33a shows a similar expression pattern (C) to the main cluster.