Bacterial internalization is decreased in DMOG treated cells.

<p>To mimic hypoxia, A549 cells were pre-treated with 1 mM of the pan-hydroxylase inhibitor DMOG or its' solvent DMSO for 24 h and throughout following infection with the <i>P. aeruginosa</i> reference strain ATCC 27853 (A), a CF pathogen <i>B. cenocepacia</i>, <i>J2315</i> (B) and two clinical <i>P. aeruginosa</i> isolates from CF patients, S7587, mucoid and non-mucoid <i>P. aeruginosa</i> (C and D). Data represent mean ± SEM of 3 independent experiments throughout (* p<0.05; *** p<0.0001).