DMOG improves survival in a murine <i>P. aeruginosa</i> pneumonia model.

<p>Pneumonia was induced by instillation of 1.5×10⁷ CFU/mouse of <i>P. aeruginosa.</i> Mice were assigned to four groups (n = 10 per group): pneumonia alone (control group), DMOG treatment (8 mg/mouse, intraperitoneally) at the time of infection with <i>P. aeruginosa</i>, DMOG treatment 24 hours prior to infection and DMOG treatment 48 hours prior to infection. DMOG treatment 48 h before infection significantly increased survival of mice with a mortality of only 20% at 48 hpi and a final mortality rate of 30% compared to 80–100% in the other groups.