HGF signaling induces proliferation and scattering of MLE12 cells.

<p>A. Proliferation dose response of HGF and EGF treatment of MLE12 cells demonstrating a significant induction of proliferation by HGF. *p<0.05. B. Proliferation response of MLE12 cells transfected with <i>MET</i> or a control vector showing increased proliferation resulting from <i>MET</i> transfection. C. Cell dispersion images of MLE12 cells treated with EGF or HGF compared to media control. D. Effect of HGF treatment on staurosporine induced caspase 3 cleavage. ST-staurosporine. All cell experiments performed in triplicate. CC3-cleaved caspase 3. E. Densitometric quantitation of effect of HGF treatment on staurosporine induced caspase 3 cleavage. F. Survival time-course of primary alveolar epithelial cells from control and <i>Met</i>-deficient mice. *p<0.05. G. Relative expression of <i>Gclc</i> and <i>Nqo1</i> with HGF treatment of primary murine alveolar epithelial cells. *p<0.05 compared with control conditions.