A Simple Protocol for NMR Analysis of the Enantiomeric Purity of Chiral Hydroxylamines
- David A. Tickell (1991902)
- Mary F. Mahon (1293876)
- Steven D. Bull (1652206)
- Tony D. James (1430470)
Publication date
February 2013
DOIAbstract
A practically simple three-component chiral derivatization protocol for determining the enantiopurity of chiral hydroxylamines by <sup>1</sup>H NMR spectroscopic analysis is described, involving their treatment with 2-formylphenylboronic acid and enantiopure BINOL to afford a mixture of diastereomeric nitrono-boronate esters whose ratio is an accurate reflection of the enantiopurity of the parent hydroxylamine
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