The correlation between gene expression levels and response to IFN-α/5-FU therapy.

<p>(A) Survival rates of responders and nonresponders treated with IFN-α/5-FU. *<i>P</i><0.05 between groups. (B) The correlation between protein kinase, adenosine monophosphate (AMP)-activated, gamma 2 non-catalytic subunit (<i>PRKAG2</i>) mRNA and survival period in patients treated with IFN-α/5-FU therapy. Data were analyzed using Spearman’s rank correlation test. (C) The correlation between transforming growth factor-beta receptor II (<i>TGFBR2</i>) mRNA and survival period in patients treated with IFN-α/5-FU therapy. Data were analyzed using Spearman’s rank correlation test. (D, E) Immunohistochemical analysis of PRKAG2 (D) and TGFBR2 (E) expression.