Multivariate analysis of the model combing GSP and tumor grade improves the prognosis of DMFS for both.

<p>The multivariate analysis combining the GSP and tumor grade shows that, in each of the three tumor grade sub-cohorts, the positive individualized prognostic index confers poor DMFS. The multivariate analysis p-values are 0.055, 0.024 and 0.018 and hazard ratios are 1.5, 1.6 and 0.4 for GSP, tumor grade III and tumor grade I, respectively; the p-value for the overall model is 2.7e–6.