<p>This data set represents the number of cocaine infusions each subject earned for the last two days preceding (2a), and for the two consecutive sessions during (2b), the dose-response challenge for mice of each genotype. TRPC5 +/+ = wild-type; TRPC5 -/- = knock-down; "-2" = second to last day leading up to dose-response challenge; "-1" = last day leading up to dose-response challenge; S(0.05) = session with dose 0.05 mg/kg/infusion; S(0.1) = session with dose 0.1 mg/kg/infusion; S(0.75) = session with dose 0.75 mg/kg/infusion; S(2.0) = session with does 2.0 mg/kg/infusion; S1 = first daily session with respective dose; S2 = second daily session with respective dose</p
RATIONALE: Cocaine addiction is a major public health problem with a substantial genetic basis for w...
<p>Changes in BSR threshold (<b>A</b>) and maximum operant response rate (MAX, <b>B</b>) in the firs...
The faster drugs of abuse reach the brain, the greater is the risk of addiction. Even small differen...
<p>This data set represents the number of infusions (1a) and the frequency of nose-pokes in the acti...
<p>The graph shows the number of self-infusion on the last 5 days of acquisition (day 6–10) and the ...
<p>Graphs show the number of self-infusions obtained in (a) C57 mice in acquisition at 1 mg/kg/infus...
<p><b>A)</b> The number of cocaine infusions earned by βarr1 KO mice (KO: n = 21) during the first 5...
<p>(A) Context dependent sensitization. Cumulative 30 min locomotor response to cocaine (15 mg/kg, i...
<p>After three days of saline injections, WT and β2m<sup>−/−</sup> mice were divided into groups tha...
<p><b>Copyright information:</b></p><p>Taken from "Cocaine reward and locomotion stimulation in mice...
<p><b>Copyright information:</b></p><p>Taken from "Cocaine reward and locomotion stimulation in mice...
<p>(A) Drug-naïve <i>Dbh +/−</i> (n = 9) and <i>Dbh −/−</i> mice (n = 8) were placed in automated lo...
<p>Cocaine-induced locomotor activity in DAT/5-HT1B KO mice is expressed as absolute difference s fr...
Initial sensitivity to psychostimulants can predict subsequent use and abuse in humans. Acute locomo...
Behavioural activation repeatedly induced by a stimulant in rodents can persist in the absence of th...
RATIONALE: Cocaine addiction is a major public health problem with a substantial genetic basis for w...
<p>Changes in BSR threshold (<b>A</b>) and maximum operant response rate (MAX, <b>B</b>) in the firs...
The faster drugs of abuse reach the brain, the greater is the risk of addiction. Even small differen...
<p>This data set represents the number of infusions (1a) and the frequency of nose-pokes in the acti...
<p>The graph shows the number of self-infusion on the last 5 days of acquisition (day 6–10) and the ...
<p>Graphs show the number of self-infusions obtained in (a) C57 mice in acquisition at 1 mg/kg/infus...
<p><b>A)</b> The number of cocaine infusions earned by βarr1 KO mice (KO: n = 21) during the first 5...
<p>(A) Context dependent sensitization. Cumulative 30 min locomotor response to cocaine (15 mg/kg, i...
<p>After three days of saline injections, WT and β2m<sup>−/−</sup> mice were divided into groups tha...
<p><b>Copyright information:</b></p><p>Taken from "Cocaine reward and locomotion stimulation in mice...
<p><b>Copyright information:</b></p><p>Taken from "Cocaine reward and locomotion stimulation in mice...
<p>(A) Drug-naïve <i>Dbh +/−</i> (n = 9) and <i>Dbh −/−</i> mice (n = 8) were placed in automated lo...
<p>Cocaine-induced locomotor activity in DAT/5-HT1B KO mice is expressed as absolute difference s fr...
Initial sensitivity to psychostimulants can predict subsequent use and abuse in humans. Acute locomo...
Behavioural activation repeatedly induced by a stimulant in rodents can persist in the absence of th...
RATIONALE: Cocaine addiction is a major public health problem with a substantial genetic basis for w...
<p>Changes in BSR threshold (<b>A</b>) and maximum operant response rate (MAX, <b>B</b>) in the firs...
The faster drugs of abuse reach the brain, the greater is the risk of addiction. Even small differen...