SKLB023 improved histological changes and arthritis scores in DBA/1J mice.

<p>(A) Representative photographs of tarsotibial joint swelling of the hind paws in mice treated with or without SKLB023 (n = 8). (B) Representative histopathologies of the ankle joints stained with hematoxylin and eosin (H&E) in CIA. (C) Histological examinations of a total of 8 mice for each pair were scored from 0 to 4 as described in the <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0056349#s2" target="_blank">Methods</a>. (D) Arthritis scores during the progression of CIA. Error bars represented SEM, *P<0.05, **P<0.01, and ***P<0.001 indicated significant differences from the control group.