Deactivation related to fatigue and compensatory effort (n = 29).

<p>All voxels were significant at a statistical threshold of <i>p</i><0.05 for family wise error (FWE) corrected for multiple comparisons. Fatigue-induced deactivation in the H condition (i.e., PreH – PostH) (A), fatigue-induced deactivation in the E condition (i.e., PreE – PostE) (B), and deactivation reflecting the compensatory effort (i.e., [PreH – PostH] – [PreE – PostE]) (C). The activation profile of each area represents the parameter estimates in each condition. Errors bar represent the standard errors. The coordinates in the MNI standard space are indicated. E, Easy; H, Hard; Post, the last three runs again in the magnetic resonance imaging (MRI) scanner; Pre, the first three runs in the MRI scanner.