Lack of compartmentalized Peyer’s patches (PP) in <i>Sharpin^cpdm</i> mutant mice.

<p>(A) Intercellular adhesion molecule (ICAM1) labeling in the small intestine of 1 day old mice. Numerous ICAM1⁺ patches are present in the <i>Sharpin^cpdm</i> mutant mice (left), however they lack the distinct compartmentalization seen in most ICAM1⁺ patches of control (+/?) mice (right). (B) Mean ICAM1⁺ counts for a litter of 1 day old <i>Sharpin^cpdm</i> mutant (N = 3) and control (+/?) mice (N = 8). Bars indicate standard error of the mean. (C) Anti-CD45RB (B220) labeling in the small intestine of mutant <i>Sharpin^cpdm</i> (top panel) and control (bottom panel) mice at (left) 4 days, (center) 1 week, and (right) 2 weeks of age. Images are representative of 3 to 4 mice per group; PP of control mice appear compartmentalized and follicular structures are evident, and overall size of PP subjectively increase with age, while those of mutant mice do not show these features. WMI.