Cytokine and chemokine levels are increased in the mouse pancreas and lung in ligation-induced acute pancreatitis.

<p>A) <i>Cytokines</i> IL-1β, TNF-α and IL-6 were assayed in the pancreas of mice after 24, 48 or 72 hrs of pancreatic duct ligation (PD)(IL-6 was also assayed in the lung). B) <i>Chemokines</i> CCL2/MCP-1 and CXCL2/MIP-2α were assayed in the pancreas and lung of mice after 24, 48 or 72 hrs of PD. There was a significant increase in cytokine and chemokine concentration in the tissue homogenates from pancreatitic mice versus sham control groups. ELISA, data are mean ± SEM; Student's t-test; asterisk (*) indicates significance versus sham control group at the corresponding time point, p<0.05.