Representative photographs of renal damage markers in adriamycin-exposed and control kidneys.
- Katarina Mirković (284474)
- Carolina R. C. Doorenbos (284475)
- Wendy A. Dam (284476)
- Hiddo J. Lambers Heerspink (284477)
- Maartje C. J. Slagman (284478)
- Ferdau L. Nauta (162002)
- Andrea B. Kramer (284479)
- Ronald T. Gansevoort (284480)
- Jacob van den Born (167146)
- Gerjan Navis (111256)
- Martin H. de Borst (123754)
Publication date
February 2013
DOIAbstract
<p>Interstitial α-SMA increased progressively in proteinuric kidneys during follow up (A, B). α-SMA was located around dilated tubules (arrows) and in blood vessels (arrowheads). In control kidneys at week 30, only very limited expression of interstitial α-SMA was present (C). Interstitial macrophage influx increased in ADR animals (D, E). ED-1 positive cells were found mostly around damaged tubules (arrows) and sporadically present in the interstitium of control kidneys (F). Immunostaining of collagen III was found in ADR animals (G, H; arrows), and rarely in controls (I).</p
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