High fat-induced expression of inflammatory cytokines and chemokines is attenuated in caspase-1 knockout mice.

<p>Inflammatory cytokine/chemokine production in the liver is associated the early stages of NASH. mRNA expression for Tnfα (A), Mcp-1 (B) and F4/80 (C) in the liver of wild-type mice on control or high fat diets was performed by RT-PCR. Values represent means ± SEM. Values with different superscripts are significantly different from one another (<i>p</i><0.05). n = 4 control, n = 6 high fat.