Contractile effects of an α₁ adrenergic receptor agonist and thromboxane A₂ receptor agonist on untreated mouse aortas across PAR2 genotypes.

<p>Male (top) and female (bottom) aortic rings were contracted by the cumulative addition of phenylephrine (a, c) and U46619 (b, d) under isometric tension conditions. Symbols are means ± S.E.M., n = number of mice. Lines represent 4 parameter logistic curves which calculate the variables: pD₂, E_max and hill-slope. Variables were compared by 2 way ANOVA (sex x genotype). (c) ^Φ<i>P</i><0.05, hill-slope, main gender effect.