a<p>Values represent mean ± SD of at least three independent experiments, each performed in triplicate.</p>b<p>Fold of resistance was calculated as the IC<sub>50</sub> values of paclitaxel, docetaxel, vincristine, vinblastine, vinorelbine or cisplatin of HEK/pcDNA or HEK/MRP7 cells in the absence or presence of reversal agents divided by the IC<sub>50</sub> values of paclitaxel, docetaxel, vincristine, vinblastine, vinorelbine or cisplatin of HEK/pcDNA cells without the reversing agents.</p>*<p>: <i>P<0.05</i>.</p
The growth inhibitory effect of paclitaxel, docetaxel, and newly developed taxanes IDN5109, IDN5111,...
In vitro synergy has been reported for exposure to paclitaxel prior to cis-platin (cis-DDP), whereas...
Backgroud: The effectiveness of chemotherapy is limited by the emergence of multidrug resistance (MD...
<p>HEK/pcDNA cells and HEK/MRP7 cells were cultured for 24 h before tariquidar was added. After 1 h ...
<p>The accumulation of [<sup>3</sup>H]-paclitaxel was measured after preincubation in the presence o...
<p>Panel A, B, C, D, E, F: the survival curves of parental HEK293/pcDNA3.1 and HEK293/MRP7 cells wit...
<p>The efflux assay was performed as described in <a href="http://www.plosone.org/article/info:doi/1...
Background: Ineffectiveness of anticancer drugs is frequently observed in cancer chemotherapy. The r...
<p>The cytotoxicity of 21α-MMD (6.25–100 μM), paclitaxel (12.5–200 μM), and 5-FU (2–60 μM) alone or ...
The effect on cytotoxicity of combining a range of clinically important non-steroidal anti-inflammat...
<p>Two cell lines, HEK293-pcDNA3.1 and HEK-MRP7-2, are represented as HEK293 and MRP7, respectively....
<p>(A) Sensitization of MA cells to chemotherapeutic drugs by prior treatment with sodium valproate....
topoisomerase I poison that exhibits antineoplastic activity. Analysis of the cytotoxic effects of c...
<p>(A) Cells were treated with varying concentration of verapamil for 24 h. Thereafter medium was re...
The cells developing resistance to an applied drug may also present cross-resistance to other antica...
The growth inhibitory effect of paclitaxel, docetaxel, and newly developed taxanes IDN5109, IDN5111,...
In vitro synergy has been reported for exposure to paclitaxel prior to cis-platin (cis-DDP), whereas...
Backgroud: The effectiveness of chemotherapy is limited by the emergence of multidrug resistance (MD...
<p>HEK/pcDNA cells and HEK/MRP7 cells were cultured for 24 h before tariquidar was added. After 1 h ...
<p>The accumulation of [<sup>3</sup>H]-paclitaxel was measured after preincubation in the presence o...
<p>Panel A, B, C, D, E, F: the survival curves of parental HEK293/pcDNA3.1 and HEK293/MRP7 cells wit...
<p>The efflux assay was performed as described in <a href="http://www.plosone.org/article/info:doi/1...
Background: Ineffectiveness of anticancer drugs is frequently observed in cancer chemotherapy. The r...
<p>The cytotoxicity of 21α-MMD (6.25–100 μM), paclitaxel (12.5–200 μM), and 5-FU (2–60 μM) alone or ...
The effect on cytotoxicity of combining a range of clinically important non-steroidal anti-inflammat...
<p>Two cell lines, HEK293-pcDNA3.1 and HEK-MRP7-2, are represented as HEK293 and MRP7, respectively....
<p>(A) Sensitization of MA cells to chemotherapeutic drugs by prior treatment with sodium valproate....
topoisomerase I poison that exhibits antineoplastic activity. Analysis of the cytotoxic effects of c...
<p>(A) Cells were treated with varying concentration of verapamil for 24 h. Thereafter medium was re...
The cells developing resistance to an applied drug may also present cross-resistance to other antica...
The growth inhibitory effect of paclitaxel, docetaxel, and newly developed taxanes IDN5109, IDN5111,...
In vitro synergy has been reported for exposure to paclitaxel prior to cis-platin (cis-DDP), whereas...
Backgroud: The effectiveness of chemotherapy is limited by the emergence of multidrug resistance (MD...