Lack of involvement of T cells and B cells in LPS induced airway inflammation.

<p>BAL total and differential cell counts (<b>A</b>) were determined and compared between LPS stimulated RAG-1 KO and WT mice; <i>mev</i>/+/RAG-1 KO and <i>mev</i>/+ mice (NS = not significant). (<b>B</b>). Lung histology of LPS stimulated <i>mev</i>/+ and <i>mev</i>/+/RAG-1 KO mice (Magnification 20x). (<b>C</b>). Effects of alveolar macrophage depletion on LPS induced airway inflammation and SHP-1 regulation. WT and <i>mev</i>/+ mice received airway administration (i.t.) of Clodronate (Clo)-Liposome or PBS-Liposome 24 hrs prior to LPS stimulation. BAL total and differential cell counts were determined and compared after LPS stimulation as described above (n = 5 for each group; <b>*</b><i>P</i><0.05; <b>**</b><i>P</i><0.01).