RI-OR2-TAT inhibits the toxic effects of Aβ42 on cells.

<p>(<b>A</b>) The black bars show data for the viability of SHSY-5Y neuroblastoma cells, as measured by LDH assay, following exposure to 12.5, 25, 50, 100 and 200 µM RI-OR2-TAT alone for 24 h. The light grey ‘Con’ bar shows data for cells maintained under the same conditions, but without RI-OR2-TAT, and the dark grey bar shows data for lysed cells. (<b>B</b>) Shows the ability of RI-OR2-TAT to protect against Aβ42-mediated toxicity. The black bars are LDH assay data for cells grown in the presence of 5 µM Aβ42 plus 0.1, 0.5, 1, 5 or 10 µM RI-OR2-TAT for 24 h. The ‘0’ bar shows data for cells grown in the presence of Aβ42 alone and the bars labelled ‘Con’ and ‘Lysed cells’ are the same as for (<b>A</b>). For both (<b>A</b>) and (<b>B</b>) *indicates p<0.05.