Overall survival of cancer patients with Foxp3+ cancer cell expression in their CRCs compared with the overall survival of those with infiltrated Foxp3+ Treg in their tumors.

<p>(<b>A</b>) Patients with high Foxp3+ cancer cell expression (>16%, as mean cut-off) had a poorer prognosis than those with low Foxp3+ cancer cell expression profiles (<16%; mean cut-off: 16%), (p<0.001, Log-Rank test). (<b>B</b>) No significant difference in the overall survival comparing patients with low and high Foxp3+ Treg expression profiles (mean cut-off: 12%), (p = 0.202, Log-Rank test). (<b>C</b>) Patients with lymph node metastasis had a poorer prognosis than those without lymph node metastasis (p<0.001, Log-Rank test). The times of the censored data are indicated by short vertical lines.