Sirt1 expression is reduced in patients suffering from atherosclerotic disease. A.
- Alexander Breitenstein (286280)
- Christophe A. Wyss (286281)
- Remo D. Spescha (286283)
- Fabian C. Franzeck (126159)
- Danielle Hof (2282800)
- Meliana Riwanto (286286)
- Matthias Hasun (110122)
- Alexander Akhmedov (286287)
- Arnold von Eckardstein (126197)
- Willibald Maier (286288)
- Ulf Landmesser (214529)
- Thomas F. Lüscher (126194)
- Giovanni G. Camici (169129)
Publication date
February 2013
DOIAbstract
<p>HDL levels are reduced in patients suffering from CAD or ACS as compared to the healthy controls. <b>B.</b> Flow cytometry analysis demonstrates the purity of isolated monocytes. <b>C.</b> Sirt1 mRNA expression in relation to 18S rRNA in peripheral blood monocytes isolated from healthy subjects, from patients with angiographically-confirmed CAD and patients presenting with an ACS. <b>D.</b> The expression of interleukin-6 (IL-6), a negatively regulated Sirt1-dependent marker, is increased in patients with impaired Sirt1-expression.</p
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