Detection of substitution.

<p>a) Signal intensity ratio of DH1 to W3110 in a candidate region. The horizontal axis represents the position of the probe in the genome and the vertical axis represents intensity ratio of the DH1 to the wild type. Black circles represent the intensity ratio of PM probes, and letters a,c,g,t represent those of MM probes with corresponding substitutions. The intensity in DH1 drops around a mutation due to mismatch, but there is a mismatch probe that shows higher intensity in DH1 than that in W3110 (show by the red arrow). (b) Log likelihood ratio evaluated from the intensity ratio. The vertical axis represents the likelihood that there is a mutation at that position.