Genistein sensitizes bladder cancer cells to HCPT treatment.

<p><b>A.</b> MTT assay of bladder cancer cell lines and BDEC cells treated with 10 µM genistein and/or 1 µM HCPT; results are expressed as percentage of control cells. <b>B</b>. MTT assay of TCCSUP and BDEC cells treated with different concentrations of HCPT and/or genistein for 48 h. <b>C.</b> Cell cycle distribution of TCCSUP or BDEC treated with 1 µM HCPT and/or 10 µM genistein for 24 h. <b>D.</b> Apoptosis measured by FACS in TCCSUP, and BDEC treated with 10 µM genistein and/or 1 µM HCPT. Values are mean ± SEM of three independent experiments; *<i>P</i><0.05 and **<i>P</i><0.01 compared with control group. #<i>P</i><0.05 and ##<i>P</i><0.01 compared with HCPT; @<i>P</i><0.05 and @@P<0.01 compared with genistein.