Biodistribution of surface-modified adenoviruses in mice after intravenous injection.

<p>Ad5(GFP), Ad5PTD(GFP), Ad5f35(GFP) and Ad5PTDf35(GFP) virus vectors (evg = 5×10⁹) were injected intravenously (tail-vein) into female balb/c mice and organs were harvested 48 hours post-virus injection. Viral genome DNA was isolated from the various organs and quantified by quantitative PCR in triplicates. Viral genome copy per tissue weight (mg) are shown as mean+SD (n = 3). One-way ANOVA with Tukey post test was used for comparison between different groups. #: Blood values are based on 100 µl blood from sacrificed mice and bone marrow (BM) values are based on 5×10⁶ cells. *:p<0.05.