FTY720 attenuates carrageenan-induced thermal hyperalgesia and neutrophilic recruitment.

<p>Intraplantar injection of carrageenan (1%) led to a time- dependent development of thermal hyperalgesia. A) Pretreatment with the non-selective functional antagonist, FTY720 (0.1 mg/kg – 1.0 mg/kg, n = 7) attenuated the development of thermal hyperalgesia in response to carrageenan in a dose-dependent manner. B) FTY720 (1 mg/kg, n = 7) attenuated carrageenan-induced increases in neutrophilic recruitment. Results are expressed as mean ± SEM and analyzed by two-way repeated measures ANOVA with Bonferroni <i>post hoc</i> test for behavior and one-way ANOVA with Dunnetts <i>post hoc</i> test for MPO, where *<i>P</i><0.05, **<i>P</i><0.001 <i>vs</i>. carrageenan; † <i>P</i><0.01 †† <i>P</i><0.001 <i>vs</i>. vehicle.