pAdEasy backbone vectors for production of recombinant adenovirus.
- Di Yu (254015)
- Chuan Jin (286808)
- Mohanraj Ramachandran (286810)
- Jing Xu (15337)
- Berith Nilsson (254014)
- Olle Korsgren (286811)
- Katarina Le Blanc (28322)
- Lene Uhrbom (286812)
- Karin Forsberg-Nilsson (145089)
- Bengt Westermark (265947)
- Rachel Adamson (286813)
- Norman Maitland (286814)
- Xiaolong Fan (255637)
- Magnus Essand (229711)
Publication date
February 2013
DOIAbstract
1<p>The backbone plasmids without the adenoviral E3 region are intended for production of vectors for genetic vaccine/gene delivery, while the E3-containing plasmids are more suitable for oncolytic virus development.</p>2<p>A Tat-PTD sequence was inserted in hypervariable region 5 of the adenovirus hexon.</p>3<p>The fiber (shaft and knob) was replaced with the corresponding sequences from adenovirus serotype 35.</p
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