Increased JAM-C expression has no influence on islet infiltration, viral clearance or antigen specific immune response.

<p>- (A) Pancreas sections of RIP-LCMV-GP × pHHNS–JAM-C transgenic mice were stained with Hämatoxylin and the insulitis score was obtained from sections of 3 mice per group (number of islets analyzed per group are indicated). Scoring system: 0, no infiltration; 1, some peri-insular infiltration; 2, heavy peri-insular infiltration with some intra-insular infiltrates; 3, heavy intra-insular infiltration and/or islet scars. (B) Virus titers in the pancreas (P) and spleen (SP) on days 3, 7 and 14 after infection. Data are the mean ± SD of 3–4 mice per group. Det limit: Minimal number of plaques at highest tissue homogenate concentration required for statistical evaluation. (C) The presence of GP₃₃-specific CD8⁺ T cells on day 10 after LCMV-infection in the spleen and PDLN of RIP-LCMV-GP or RIP-LCMV-GP × pHHNS-JAM-C mice was analyzed by intracellular cytokine staining (IFN-γ) after o/n <i>in vitro</i> stimulation with GP₃₃ peptide. Data are the mean ± SD of six mice per group.