Genistein sensitizes TCCSUP tumors to HCPT in a SCID xenograft model.

<p>TCCSU bladder cancer cell tumors were allowed to establish for 22 days, then the animals were injected intratumorally with 10 µM genistein and/or 10 µM HCPT on day 0 and 7 of treatment. <b>A</b>. Growth curve of TCCSUP bladder cancer xenografts treated with genistein and/or HCPT; tumor volume is expressed relative to tumor size at the start of treatment. <b>B</b>. EMSA assay of NF-κB expression in xenograft tumor tissues from each group. <b>C</b>. Western blot analysis of phosphorylated IKK1/2, IKK2, IκBα expression in xenograft tumor tissues from each group.