Effects of CXB analogues on neuropathic pain in chronic constriction injury (CCI) rats.

<p>CCI rats were given CXB, DMC, RTG (30 mg/kg/day) or solvent (intragastric (<i>i.g</i>) administration twice a day) from 1∼14 days after surgery. A, Effects of CXB, DMC and RTG on rat pain behavior responding to the mechanical stimuli. Mechanical thresholds (g) were measured using calibrated Von Frey filaments applied to the plantar surface of the ipsilateral hind paw before operation and 1day, 5days, 10 days and 14 days after the surgery. *<i>P</i> <0.05, ***<i>P</i> <0.001, CXB group compared with the solvent group., ^###<i>P</i> <0.001, RTG group compared with the solvent group, ⁺⁺⁺<i>P</i> <0.001, DMC group compared with the solvent group. B, Effects of CXB, DMC and RTG on rat pain behavior responding to the thermal stimuli. Thermal withdrawal latencies of the ipsilateral hind paw were measured using radiant heat from underneath the glass floor with a high-intensity lamp bulb before operation and 1 day, 5 days, 10 days and 14 days after surgery. *<i>P</i> <0.05, CXB group compared with the solvent group.