Heatmap and clustering analysis of HIV-1 specific cross-reactive neutralizing activity in serum.

<p>IC₅₀ values of sera from 292 HIV-1 infected individuals at ∼35 months post (imputed) seroconversion (rows) against 6 viral isolates (columns) are shown. Darker colors represent more potent neutralization. Kmeans clustering was performed on the rows and the columns and the rows/columns that fall in the same cluster are represented by the same colors on the row/column side bar. Patients with cross-reactive neutralizing activity (CrNA) cluster together in the upper heatmap and patients with no CrNA cluster in the bottom of the heatmap.