Effect of IKKi on the MAPK and AKT/GSK3β/mTOR/FOXO/NFκB signaling pathways.

<p>(A–D) Levels of total and phosphorylated MEK1/2, ERK1/2, JNK, P38PI3K, AKT, GSK3β, mTOR, FOXO and NFκB in the heart tissues of mice in the indicated groups (n = 6). A and C Representative blots. B and D Quantitative results. (E–F) Representative blots for total and phosphorylated AKT, GSK3β, mTOR, FOXO3A, FOXO1 and NFκB after treatment with Ang II for the indicated times in H9c2 rat cardiomyocytes infected with Ad-GFP or Ad-IKKi. E Representative blots. F, Quantitative results. *<i>P</i><0.05 vs. WT/sham; # <i>P</i><0.05 vs. WT/AB after AB.