The effect of sulodexide on phosphorylated PKC-α expression in the kidneys of control and DN C57BL/6 mice.

<p>Representative images of (A) phosphorylated PKC-α in control and DN mice at baseline and after 12 weeks treatment with saline or sulodexide are shown. Original magnification x1000. Image-based computer assisted analysis was performed to semi-quantify the amount of phosphorylated PKC-α in the (B) glomeruli and (C) tubulo-interstitium of control and DN mice. Results are expressed as mean+SD of data obtained from 6 mice per group. ^§§§<i>P</i><0.001, compared to baseline for the same group, ^###<i>P</i><0.001, DN baseline vs non-diabetic baseline, ***<i>P</i><0.001, DN mice vs non-diabetic mice for the same treatment, ^‡‡‡<i>P</i><0.001, saline vs sulodexide treatment for the same time-point in DN mice.