Blood urea nitrogen (BUN) and creatinine in rats after burn.

<p>Analysis of burn-induced late renal dysfunction evidenced by BUN and creatinine (<b>A–B</b>) at different time points of 3 h, 6 h, 24 h, 48 h and 72 h and (<b>C–D</b>) with different treatments at 72 h postburn. The data showed that burn induced a late renal dysfunction at 72 h, which was improved by inhibiting reactive oxygen species (ROS) or p38 MAPK with tempol or SB203580, and deteriorated by inhibiting Akt expression at 72 h. Treatment with tBHP also caused significant renal dysfunction. *<i>P</i><0.05, **<i>P</i><0.01 vs. Sham; ^#<i>P</i><0.05, ^##<i>P</i><0.01 vs. Vehicle. n = 6 rats per group per time point.