The inhibitory effects of cisplatin on the proliferative capacity of cisplatin resistant NSCLC cells.

<p>Parent (PT) and cisplatin resistant (CisR) cell lines were treated with increasing concentrations of cisplatin for 72 h. Proliferation was measured using the MTT assay. While cisplatin inhibited the growth of both PT and CisR cell lines, the inhibitory effect of cisplatin was greatly reduced in CisR cells relative to parent cells. Data are expressed as Mean ± SEM from three independent experiments (n = 3) (*p<0.001 vs PT untreated, ^$$p<0.001 vs CisR untreated, ^#p<0.001 PT vs CisR,^$p<0.01 vs CisR untreated [A549], ^$p<0.01 PT vs CisR, ^#$p<0.05 PT vs CisR [MOR]).